...Retinoic acid binds to all three kinds of retinoid receptors: alpha, beta, and gamma. It is thought that the gamma receptor is the most important in the pathogenesis of acne, and retinoic acid has a very high affinity for gamma receptors. First of all, there is sebum. Sebum itself might be comedogenic, but whether it is or not, it certainly provides the nutrient material for P acnes. The proliferation of this microorganism is the next pathogenic factor. ...»
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«...Sebum is an oil naturally produced by your skin. This oil helps to keep your skin supple and healthy. It's the combination of this oil and the bacteria that causes acne and pimples. The blockage is caused when your skin's pores close, and this traps the bacteria with the oil. The pain is caused by the pressure that builds up under the skin....»
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